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Theophilus et al., 2015) carried out feeding experiments lasting for 90 days and 2 years, with feeds including basic diet, tobacco blend mixed feed, tobacco blend water extract mixed feed and nicotine

Overall, the pattern of e-cigarette use by demographic distribution and by smoking status is consistent with those from developed countries as well 26

Smoking has important negative effects on general health, such as an increased risk of certain types of cancer and cardiovascular problems

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